論文 - 詳細
RRC ID | 73002 |
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著者 | Eguchi T, Kanai S, Kakinuma K, Okazaki T, Mizoue K. |
タイトル | Synthesis of NG-061 and its analogs, and their biological evaluation as an enhancer of nerve growth factor. |
ジャーナル | Chem Pharm Bull (Tokyo) |
Abstract |
A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was synthesized from methoxybenzoquinone and phenylacetylhydrazine in a single step. A series of acyl hydrazone derivatives were also synthesized and their potentiator activity of neurotrophic effect of NGF on neurite outgrowth was evaluated by assay with a rat pheochromocytoma cell line PC12. |
巻・号 | 48(10) |
ページ | 1470-3 |
公開日 | 2000-10-1 |
DOI | 10.1248/cpb.48.1470 |
PMID | 11045453 |
MeSH | Animals Drug Evaluation, Preclinical Hydrazines / chemical synthesis* Hydrazines / chemistry Hydrazines / pharmacology Molecular Structure Nerve Growth Factor / agonists* PC12 Cells Phenylacetates / chemical synthesis* Phenylacetates / chemistry Phenylacetates / pharmacology Rats Spectrum Analysis |
IF | 1.416 |
リソース情報 | |
ヒト・動物細胞 | PC-12(RCB0009) |