| RRC ID |
73739
|
| 著者 |
Tanaka Y, Furuhata E, Maeda S, Kishima M, Suzuki H, Suzuki T.
|
| タイトル |
A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells.
|
| ジャーナル |
Sci Data
|
| Abstract |
Hepatocytes are a major parenchymal cell type in the liver and play an essential role in liver function. Hepatocyte-like cells can be differentiated in vitro from induced pluripotent stem cells (iPSCs) via definitive endoderm (DE)-like cells and hepatoblast-like cells. Here, we explored the in vitro differentiation time-course of hepatocyte-like cells. We performed methylome and transcriptome analyses for hepatocyte-like cell differentiation. We also analyzed DE-like cell differentiation by methylome, transcriptome, chromatin accessibility, and GATA6 binding profiles, using finer time-course samples. In this manuscript, we provide a detailed description of the dataset and the technical validations. Our data may be valuable for the analysis of the molecular mechanisms underlying hepatocyte and DE differentiations.
|
| 巻・号 |
10(1)
|
| ページ |
93
|
| 公開日 |
2023-2-14
|
| DOI |
10.1038/s41597-023-02001-9
|
| PII |
10.1038/s41597-023-02001-9
|
| PMID |
36788249
|
| PMC |
PMC9929325
|
| MeSH |
Cell Differentiation*
Endoderm
Hepatocytes
Humans
Induced Pluripotent Stem Cells*
Liver
|
| IF |
5.541
|
| リソース情報 |
| ヒト・動物細胞 |
201B7(HPS0063) |
