| RRC ID |
74297
|
| 著者 |
Fleming T, Kikuchi Y, Nakajo M, Tachizawa M, Inazumi T, Tsuchiya S, Sugimoto Y, Saito D, Suyama M, Ohkawa Y, Baba T, Morohashi KI, Okubo K.
|
| タイトル |
Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka.
|
| ジャーナル |
Commun Biol
|
| Abstract |
In vertebrates, female receptivity to male courtship is highly dependent on ovarian secretion of estrogens and prostaglandins. We recently identified female-specific neurons in the medaka (Oryzias latipes) preoptic area that express Npba, a neuropeptide mediating female sexual receptivity, in response to ovarian estrogens. Here we show by transcriptomic analysis that these neurons express a multitude of neuropeptides, in addition to Npba, in an ovarian-dependent manner, and we thus termed them female-specific, sex steroid-responsive peptidergic (FeSP) neurons. Our results further revealed that FeSP neurons express a prostaglandin E2 receptor gene, ptger4b, in an ovarian estrogen-dependent manner. Behavioral and physiological examination of ptger4b-deficient female medaka found that they exhibit increased sexual receptivity while retaining normal ovarian function and that their FeSP neurons have reduced firing activity and impaired neuropeptide release. Collectively, this work provides evidence that prostaglandin E2/Ptger4b signaling mediates the estrogenic regulation of FeSP neuron activity and female sexual receptivity.
|
| 巻・号 |
5(1)
|
| ページ |
1215
|
| 公開日 |
2022-11-10
|
| DOI |
10.1038/s42003-022-04195-x
|
| PII |
10.1038/s42003-022-04195-x
|
| PMID |
36357668
|
| PMC |
PMC9649691
|
| MeSH |
Animals
Estrogens
Female
Male
Neurons
Neuropeptides* / genetics
Oryzias* / genetics
Prostaglandins
Receptors, Prostaglandin E
|
| IF |
4.165
|
| リソース情報 |
| メダカ |
Fosmid clone (golwfno354_c17)
EST database |
| ヒト・動物細胞 |
CHO |
