Reference - Detail
| RRC ID | 76046 |
|---|---|
| Author | Ryan KC, Ashkavand Z, Sarasija S, Laboy JT, Samarakoon R, Norman KR. |
| Title | Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration. |
| Journal | Aging Cell |
| Volume | 20(10) |
| Pages | e13472 |
| Published | 2021-10-1 |
| DOI | 10.1111/acel.13472 |
| PMID | 34499406 |
| PMC | PMC8520713 |
| MeSH | Alzheimer Disease / genetics* Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / metabolism* Calcium / metabolism* Mechanistic Target of Rapamycin Complex 1 / metabolism* Mitochondria / metabolism* Neurodegenerative Diseases / genetics* Neurodegenerative Diseases / pathology Presenilins / metabolism* Signal Transduction |
| Resource | |
| C.elegans | tm6026 |