論文 - 詳細
RRC ID | 76415 |
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著者 | Tsuji M, Taira H, Udagawa T, Aoki T, Hirayama T, Nagasawa H. |
タイトル | Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress. |
ジャーナル | Chem Commun (Camb) |
Abstract |
We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon photoirradiation. This study presents a powerful tool for studying redox signaling and oxidative stress in living cells. |
巻・号 | 59(44) |
ページ | 6706-6709 |
公開日 | 2023-5-30 |
DOI | 10.1039/d3cc01192e |
PMID | 37190960 |
MeSH | Hydrogen Peroxide Oxidation-Reduction Oxidative Stress* Peroxides* / pharmacology Reactive Oxygen Species tert-Butylhydroperoxide / pharmacology |
IF | 5.996 |
リソース情報 | |
ヒト・動物細胞 | MCF7(RCB1904) |