| RRC ID |
78552
|
| Author |
Takeda K, Suzuki J, Sasaki Y, Watanabe A, Kamei K.
|
| Title |
Importance of Accurate Identification and Antifungal Susceptibility Testing of Aspergillus Species in Clinical Settings.
|
| Journal |
Med Mycol J
|
| Abstract |
Aspergillus species have been identified morphologically in most clinical laboratories without conducting antifungal susceptibility tests (ASTs). This review aimed to evaluate the importance of accurate identification and ASTs of Aspergillus spp. strains for adequate clinical management of Aspergillus infections. The Aspergillus spp. were identified by gene sequencing, and ASTs for itraconazole and voriconazole were conducted. In Aspergillus section Nigri, the rate of detection of cryptic species was high, and Aspergillus tubingensis with lower susceptibility to azoles was frequently identified. Azole-resistant Aspergillus fumigatus was detected at a high rate in patients with chronic pulmonary aspergillosis managed with long-term azole treatment. In conclusion, accurate identification of Aspergillus spp. and ASTs are needed to carry out appropriate treatment. Moreover, we hope that these microbiological tests will be widely used in clinical laboratories to improve clinical practice.
|
| Volume |
64(4)
|
| Pages |
95-98
|
| Published |
2023-1-1
|
| DOI |
10.3314/mmj.23-004
|
| PMID |
38030277
|
| MeSH |
Antifungal Agents* / pharmacology
Aspergillus
Aspergillus fumigatus / genetics
Azoles / pharmacology
Drug Resistance, Fungal* / genetics
Fungal Proteins / genetics
Humans
Microbial Sensitivity Tests
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Aspergillus lentulus IFM 66080 |
