| RRC ID |
78570
|
| 著者 |
Hachiya K, Deguchi Y, Hirata T, Arikawa T, Fukai H, Esashi T, Nagasawa K, Mizunoe Y, Nozaki Y, Kobayashi M, Higami Y.
|
| タイトル |
Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
|
| ジャーナル |
Sci Rep
|
| Abstract |
White adipose tissue (WAT) is critical for whole-body energy metabolism, and its dysfunction leads to various metabolic disorders. In recent years, many studies have suggested that impaired mitochondria may contribute to obesity-related decline in adipose tissue function, but the detailed mechanisms remain unclear. To investigate these mechanisms, we carried out a comprehensive analysis of WAT from mice with diet-induced obesity. We discovered the transcription factor Parkin interactive substrate (PARIS or ZNF746), which suppresses the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a key regulator of mitochondrial biogenesis, to be accumulated in adipose progenitor cells from obese mice. Furthermore, we demonstrated that 3T3-L1 preadipocytes with overexpression of PARIS protein exhibited decreased mitochondrial biogenesis and impaired adipogenesis. Our results suggest that the accumulation of PARIS protein may be a novel component in the pathogenesis of obesity-related dysfunction in WAT.
|
| 巻・号 |
13(1)
|
| ページ |
22990
|
| 公開日 |
2023-12-27
|
| DOI |
10.1038/s41598-023-49996-0
|
| PII |
10.1038/s41598-023-49996-0
|
| PMID |
38151567
|
| PMC |
PMC10752882
|
| MeSH |
3T3-L1 Cells
Adipogenesis*
Adipose Tissue, White / metabolism
Animals
Mice
Obesity / metabolism
Organelle Biogenesis*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
Stem Cells / metabolism
Transcription Factors / metabolism
|
| リソース情報 |
| 遺伝子材料 |
CS-CDF-CG-PRE (RDB04379) |
