RRC ID |
79086
|
著者 |
Zaupa M, Nagaraj N, Sylenko A, Baier H, Sawamiphak S, Filosa A.
|
タイトル |
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish.
|
ジャーナル |
Neuron
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Abstract |
Animals constantly need to judge the valence of an object in their environment: is it potential food or a threat? The brain makes fundamental decisions on the appropriate behavioral strategy by integrating external information from sensory organs and internal signals related to physiological needs. For example, a hungry animal may take more risks than a satiated one when deciding to approach or avoid an object. Using a proteomic profiling approach, we identified the Calmodulin-interacting peptide Pcp4a as a key regulator of foraging-related decisions. Food intake reduced abundance of protein and mRNA of pcp4a via dopamine D2-like receptor-mediated repression of adenylate cyclase. Accordingly, deleting the pcp4a gene made zebrafish larvae more risk averse in a binary decision assay. Strikingly, neurons in the tectum became less responsive to prey-like visual stimuli in pcp4a mutants, thus biasing the behavior toward avoidance. This study pinpoints a molecular mechanism modulating behavioral choice according to internal state.
|
巻・号 |
112(7)
|
ページ |
1150-1164.e6
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公開日 |
2024-4-3
|
DOI |
10.1016/j.neuron.2024.01.001
|
PII |
S0896-6273(24)00001-1
|
PMID |
38295792
|
MeSH |
Animals
Calmodulin* / metabolism
Feeding Behavior / physiology
Hunger / physiology
Neurons / physiology
Proteomics
Zebrafish* / physiology
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リソース情報 |
ゼブラフィッシュ |
Tg(huC:GVP) |