論文 - 詳細
| RRC ID | 978 |
|---|---|
| 著者 | Honma Y, Sasakawa C, Tsuji T, Iwanaga M. |
| タイトル | Comparison of antimicrobial susceptibility between invasive and non-invasive Shigella organisms. |
| ジャーナル | Int J Antimicrob Agents |
| Abstract |
Antimicrobial susceptibility was determined for ten strains of Shigella spp. comparing invasive (invasion plasmid containing) and non-invasive members of each strain. The activity of the antimicrobial agents could be classified into three types from the differences between the minimum inhibitory concentration (MIC) for the invasive and non-invasive shigellae. For type 1, there was no difference between the MIC (an MIC gap) for invasive and non-invasive organisms. For type 2, the MIC for the invasive organisms of a strain was higher than that of non-invasive organisms of the strain. In the third type, macrolides taken in by shigellae through the type III secretion apparatus, more effectively inhibited the growth of invasive than non-invasive organisms. |
| 巻・号 | 21(3) |
| ページ | 262-6 |
| 公開日 | 2003-3-1 |
| DOI | 10.1016/s0924-8579(02)00270-4 |
| PII | S0924857902002704 |
| PMID | 12636989 |
| MeSH | Anti-Bacterial Agents / administration & dosage Anti-Bacterial Agents / pharmacokinetics Anti-Bacterial Agents / pharmacology Anti-Infective Agents / administration & dosage Anti-Infective Agents / pharmacology Base Sequence DNA, Bacterial / genetics Dose-Response Relationship, Drug Drug Resistance, Bacterial / genetics Genes, Bacterial Humans In Vitro Techniques Microbial Sensitivity Tests Ofloxacin / administration & dosage Ofloxacin / pharmacology Plasmids / genetics Shigella / drug effects* Shigella / genetics Shigella / metabolism Shigella / pathogenicity* Shigella flexneri / drug effects Shigella flexneri / genetics Shigella flexneri / pathogenicity Shigella sonnei / drug effects Shigella sonnei / genetics Shigella sonnei / pathogenicity Virulence / genetics |
| IF | 4.621 |
| 引用数 | 3 |
| WOS 分野 | PHARMACOLOGY & PHARMACY INFECTIOUS DISEASES MICROBIOLOGY |
| リソース情報 | |
| 病原微生物 | Shigella? |