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  • 検索条件 : 絞込み (MeSH = Agammaglobulinaemia Tyrosine Kinase)
生物種 リソース名 タイトル
ヒト・動物細胞 StromaNKtert(RCB2350) Preclinical evaluation of combination nemtabrutinib and venetoclax in chronic lymphocytic leukemia.
ヒト・動物細胞 DT40(RCB1464) Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.
ヒト・動物細胞 DT40(RCB1464) Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation.
ヒト・動物細胞 StromaNKtert(RCB2350) Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.
ヒト・動物細胞 NALM-6(RCB1933) BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector.
ヒト・動物細胞 MC3T3-E1(RCB1126) , ST2(RCB0224) Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation.
ヒト・動物細胞 Naturally occurring Bruton's tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model.
ヒト・動物細胞 Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family.
ヒト・動物細胞 B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol.
ヒト・動物細胞 DT40(RCB1464) , Syk^(-) DT40(RCB1470) , Btk^(-) DT40(RCB1468) , PLC-γ2^(-) DT40(RCB1469) The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.
ヒト・動物細胞 Btk^(-) DT40(RCB1468) , PLC-γ2^(-) DT40(RCB1469) B cell receptor directs the activation of NFAT and NF-kappaB via distinct molecular mechanisms.
ヒト・動物細胞 DT40(RCB1464) Implication of phosphatidylinositol 3-kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt.
ヒト・動物細胞 Btk^(-) DT40(RCB1468) , PLC-γ2^(-) DT40(RCB1469) Bruton's tyrosine kinase targets NF-kappaB to the bcl-x promoter via a mechanism involving phospholipase C-gamma2 following B cell antigen receptor engagement.
ヒト・動物細胞 Btk^(-) DT40(RCB1468) Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling.
病原微生物 Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
ヒト・動物細胞 Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.
実験動物マウス RBRC00222 ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
遺伝子材料 , ヒト・動物細胞 CSII-EF-MCS-IRES2-Venus (RDB04384) , pCMV-VSV-G-RSV-Rev (RDB04393). , THP-1(RCB1189) , 293(RCB1637) Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
ショウジョウバエ DGRC#109037 The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation.
ヒト・動物細胞 Lyn^(-) DT40(RCB1471) , Lyn^(-)/Syk^(-) DT40(RCB1500) Lysine acetylation regulates Bruton's tyrosine kinase in B cell activation.