1. ホーム
  2. 一覧
論文 特許

論文 - 一覧

  • 21 Hits
  • 検索条件 : 絞込み (MeSH = Amyotrophic Lateral Sclerosis / genetics)
生物種 リソース名 タイトル
ゼブラフィッシュ Tg (hb9:Venus) , RIKEN WT Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations.
ヒト・動物細胞 201B7(HPS0063) Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein.
ゼブラフィッシュ Tg[UAS:mRFP1-TDP-43z] , Tg[UAS:mRFP1-CRY2olig] , Tg[UAS:opTDP-43z] , Tg[mnr2b-hs:EGFP-TDP-43z] , Tg[mnr2b-hs:opTDP-43h] , Tg[mnr2b-hs:opTDP-43hA315T] Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons.
ショウジョウバエ RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration.
ショウジョウバエ Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
ショウジョウバエ Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
ショウジョウバエ Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.
ショウジョウバエ RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
遺伝子材料 GFP-OPTN-WT (RDB16707) , GFP-OPTN-E50K (RDB16708) , GFP-OPTN-E478G (RDB16709) Determination of cytoplasmic optineurin foci sizes using image correlation spectroscopy.
ヒト・動物細胞 201B7(HPS0063) , HPS0251 , HPS0252 , HPS0292 A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
線虫 tm1 , tm4439 FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
遺伝子材料 CMV:TDP43-GFP (RDB15742) , CMV:GFP-TDP25 (RDB15743) , CMV:GFP-NLS-TDP25 (RDB15744) , CMV:GFP-NLSNP-TDP25 (RDB15745) , GFP-NLS NP (RDB15746) , mCherry-Ubiquitin (RDB15747). Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity.
遺伝子材料 pEF-BOS FLAG-mouse Rab29 (RDB14971) , pEF-BOS FLAG-mouse Rab29-Q67L (RDB14972) , pEF-BOS FLAG-mouse Rab29-T21N (RDB14973). C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.
遺伝子材料 Genome Network Project Human cDNA IRAL001I24 (HGY080616) FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.
線虫 tm4439 Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
線虫 tm1411 VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
線虫 tm4391 , tm4720 , tm4076 , tm4396 The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
線虫 tm1447 , tm1877 Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.
ヒト・動物細胞 NB2a(RCB2639) DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity.
ゼブラフィッシュ Tg(isl1:GFP)/rw0 Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model.