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Species Resource Title
Human and Animal Cells 32D(RCB1145) In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor.
Human and Animal Cells A640-3Y1 , dl884-3Y1 , PAb419(RCB0195) p53-independent association between SV40 large T antigen and the major cytosolic heat shock protein, HSP90.
Human and Animal Cells NB1RGB(RCB0222) Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin.
Human and Animal Cells SQ-5(RCB0110) Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation.
Human and Animal Cells 32D(RCB1145) Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors.
Human and Animal Cells K562(RCB0027) Ectopic expression of c-myc fails to overcome downregulation of telomerase activity induced by herbimycin A, but ectopic hTERT expression overcomes it.
Human and Animal Cells 3Y1-B , SR-3Y1 KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
Human and Animal Cells U251(RCB0461) Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP.
Human and Animal Cells K562(RCB0027) Herbimycin A down-regulates messages of cyclin D1 and c-myc during erythroid differentiation of K562 cells.
Human and Animal Cells RAW 264(RCB0535) Production of tumor necrosis factor induced by synthetic low-toxicity lipid A analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase-MAP kinase signaling pathway in murine macrophages.
Human and Animal Cells K562(RCB0027) Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.
Human and Animal Cells K562(RCB0027) Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.
Drosophila Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.