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  • Search Condition : Filter (MeSH = Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*)
Species Resource Title
Medaka fli::GFP (TG1206) Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka nonalcoholic steatohepatitis model.
Human and Animal Cells Hepa 1-6(RCB1638) γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6.
Human and Animal Cells Hep G2(RCB1886) Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption.
Human and Animal Cells HL60(RCB0041) , U937 Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells.
Human and Animal Cells HuCCT1(RCB1960) , YSCCC(RCB1549) Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells.
Human and Animal Cells SSP-25(RCB1293) , HuH-28(RCB1943) Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo.
Human and Animal Cells MC3T3-E1(RCB1126) Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.
Human and Animal Cells ST2(RCB0224) Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2.
Human and Animal Cells Ca9-22(RCB1976) The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.
Human and Animal Cells Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance.
Human and Animal Cells HL-60-R2(RCB1550) The possibility of simvastatin as a chemotherapeutic agent for all-trans retinoic acid-resistant promyelocytic leukemia.
Human and Animal Cells Hep G2(RCB0459) Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells.
Human and Animal Cells Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate.
Human and Animal Cells Jurkat(RCB0806) , J774 HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.
C.elegans tm4368 The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway.
Human and Animal Cells MLC-6(RCB1536) Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling.
Mice RBRC01390 Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway.
Human and Animal Cells MC3T3-E1(RCB1126) Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.