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  • 13 Hits
  • Search Condition : Filter (MeSH = Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*)
Species Resource Title
Human and Animal Cells StromaNKtert(RCB2350) Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia.
Human and Animal Cells StromaNKtert(RCB2350) The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action.
Human and Animal Cells DT40(RCB1464) Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation.
Human and Animal Cells StromaNKtert(RCB2350) AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia.
Human and Animal Cells UE6E7T-2(RCB2153) Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo.
Human and Animal Cells StromaNKtert(RCB2350) Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Human and Animal Cells StromaNKtert(RCB2350) Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.
Human and Animal Cells 9-15C(RCB2323) PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.
Human and Animal Cells StromaNKtert(RCB2350) Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells.
Human and Animal Cells UE6E7T-2(RCB2153) Targeting the proliferative and chemoresistant compartment in chronic lymphocytic leukemia by inhibiting survivin protein.
Human and Animal Cells KUSA-H1(RCB1990) , 9-15C(RCB2323) , TSt-4(RCB2116) Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration.
Human and Animal Cells Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.
Human and Animal Cells K562 , Jurkat(RCB0806) CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma.