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  • 検索条件 : 絞込み (MeSH = Proteolysis*)
生物種 リソース名 タイトル
ショウジョウバエ pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.
遺伝子材料 pAID1.2-CMV-NmScarlet-mAID (RDB19226) , pAID1.2-EF1a-NmScarlet-mAID (RDB19227) , pAIDFA-CMV-NmScarlet-mAID (RDB19228) , pAIDFA-EF1a-NmScarlet-mAID (RDB19229) , pAID1.2-CMV-linearizing in pX330 (RDB19230) , pAID-EF1a- linearizing in pX330 (RDB19231) A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair.
ヒト・動物細胞 RAW 264(RCB0535) Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
酵母 FY31941 Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast.
ヒト・動物細胞 Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
ヒト・動物細胞 Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Tau phosphorylation affects its axonal transport and degradation.
遺伝子材料 , ヒト・動物細胞 pCMV-VSV-G (RDB04392) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) , HCT116(RCB2979) Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
ショウジョウバエ An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila.
ヒト・動物細胞 MG6(RCB2403) Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.
線虫 tm1969 , tm2027 The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C.
原核生物(大腸菌) Keio collection Degp degrades a wide range of substrate proteins in Escherichia coli under stress conditions.
ヒト・動物細胞 T98G(RCB1954) High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).
ヒト・動物細胞 ATDC5(RCB0565) Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened.
ヒト・動物細胞 Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) The N-Degron Pathway Mediates ER-phagy.
ショウジョウバエ Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies.
遺伝子材料 pMRX-bsr-ss-EGFP-FM4 (RDB17364) , pMRX-bsr-ss-EGFP-FM4-TMD (RDB17365) Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1.
ヒト・動物細胞 293(RCB1637) Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.
原核生物(大腸菌) BW25113, ∆degP, ∆hdeA, and ∆degQ DegP functions as a critical protease for bacterial acid resistance.
ショウジョウバエ 7765R-1 Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons.
実験動物マウス RBRC05323 A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage.