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  • Search Condition : Filter (MeSH = Sirtuins / metabolism*)
Species Resource Title
Human and Animal Cells WI-38(RCB0702) , HeLa ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation.
Human and Animal Cells MG6(RCB2403) Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.
Human and Animal Cells ATDC5(RCB0565) Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.
C.elegans tm2256 C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.
Human and Animal Cells TE-4(RCB2097) , TE-8(RCB2098) , TE-9(RCB1988) , TE-11(RCB2100) Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma.
Prokaryotes E. coli ASKA plasmid pCA24N Deacetylation of topoisomerase I is an important physiological function of E. coli CobB.
C.elegans tm1037 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
C.elegans tm2648 , tm2673 Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
C.elegans NA C. elegans sirtuins.
Human and Animal Cells A549 , Lu99(RCB1900) SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
Human and Animal Cells 293(RCB1637) Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a).
C.elegans tm3223 Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.