| RRC ID |
11698
|
| 著者 |
Gallio M, Ofstad TA, Macpherson LJ, Wang JW, Zuker CS.
|
| タイトル |
The coding of temperature in the Drosophila brain.
|
| ジャーナル |
Cell
|
| Abstract |
Thermosensation is an indispensable sensory modality. Here, we study temperature coding in Drosophila, and show that temperature is represented by a spatial map of activity in the brain. First, we identify TRP channels that function in the fly antenna to mediate the detection of cold stimuli. Next, we identify the hot-sensing neurons and show that hot and cold antennal receptors project onto distinct, but adjacent glomeruli in the Proximal-Antennal-Protocerebrum (PAP) forming a thermotopic map in the brain. We use two-photon imaging to reveal the functional segregation of hot and cold responses in the PAP, and show that silencing the hot- or cold-sensing neurons produces animals with distinct and discrete deficits in their behavioral responses to thermal stimuli. Together, these results demonstrate that dedicated populations of cells orchestrate behavioral responses to different temperature stimuli, and reveal a labeled-line logic for the coding of temperature information in the brain.
|
| 巻・号 |
144(4)
|
| ページ |
614-24
|
| 公開日 |
2011-2-18
|
| DOI |
10.1016/j.cell.2011.01.028
|
| PII |
S0092-8674(11)00067-5
|
| PMID |
21335241
|
| PMC |
PMC3336488
|
| MeSH |
Animals
Brain / physiology
Cold Temperature
Drosophila / physiology*
Drosophila Proteins / metabolism
Hot Temperature
Sensory Receptor Cells / physiology
TRPP Cation Channels / metabolism
Thermosensing
|
| IF |
38.637
|
| 引用数 |
123
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
brv1 NP4486 (DGRC#104694) |
