RRC ID 15349
著者 Momota R, Naito I, Ninomiya Y, Ohtsuka A.
タイトル Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution.
ジャーナル Matrix Biol
Abstract Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piggyBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo.
巻・号 30(4)
ページ 258-66
公開日 2011-5-1
DOI 10.1016/j.matbio.2011.03.008
PII S0945-053X(11)00028-X
PMID 21477650
MeSH Amino Acid Motifs Animals Behavior, Animal Chondroitin Sulfate Proteoglycans / chemistry Chondroitin Sulfate Proteoglycans / genetics Chondroitin Sulfate Proteoglycans / metabolism* Collagen / chemistry Collagen / genetics Collagen / metabolism* Digestive System / metabolism Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Components Larva / genetics Larva / metabolism Lipid Metabolism / genetics Organ Specificity Protein Isoforms Protein Structure, Tertiary Sensory Receptor Cells / cytology Sequence Deletion Sequence Homology, Amino Acid Touch Wnt1 Protein / metabolism*
IF 8.572
引用数 14
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ DGRC#101565 DGRC#110692 Oregon-R