RRC ID 15359
著者 König A, Yatsenko AS, Weiss M, Shcherbata HR.
タイトル Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation.
ジャーナル EMBO J
Abstract Previously, it has been shown that in Drosophila steroid hormones are required for progression of oogenesis during late stages of egg maturation. Here, we show that ecdysteroids regulate progression through the early steps of germ cell lineage. Upon ecdysone signalling deficit germline stem cell progeny delay to switch on a differentiation programme. This differentiation impediment is associated with reduced TGF-β signalling in the germline and increased levels of cell adhesion complexes and cytoskeletal proteins in somatic escort cells. A co-activator of the ecdysone receptor, Taiman is the spatially restricted regulator of the ecdysone signalling pathway in soma. Additionally, when ecdysone signalling is perturbed during the process of somatic stem cell niche establishment enlarged functional niches able to host additional stem cells are formed.
巻・号 30(8)
ページ 1549-62
公開日 2011-4-20
DOI 10.1038/emboj.2011.73
PII emboj201173
PMID 21423150
PMC PMC3102283
MeSH Animals Blotting, Western Cell Adhesion Cell Differentiation / drug effects* Cell Lineage Cell Proliferation Drosophila Proteins Drosophila melanogaster / drug effects Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism* Ecdysteroids / pharmacology* Female Fluorescent Antibody Technique Gene Expression Regulation, Developmental Germ Cells / cytology* Germ Cells / drug effects* Germ Cells / metabolism Oogenesis / drug effects Ovary / cytology Ovary / drug effects Ovary / metabolism Signal Transduction Stem Cell Niche* Transcription Factors / genetics Transcription Factors / metabolism Transforming Growth Factor beta / genetics Transforming Growth Factor beta / metabolism
IF 9.889
引用数 70
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ FRT-lethal DGRC#111108