| RRC ID |
22007
|
| 著者 |
Arif S, Murat S, Almudi I, Nunes MD, Bortolamiol-Becet D, McGregor NS, Currie JM, Hughes H, Ronshaugen M, Sucena É, Lai EC, Schlötterer C, McGregor AP.
|
| タイトル |
Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster.
|
| ジャーナル |
Curr Biol
|
| Abstract |
Identifying the genetic mechanisms underlying phenotypic change is essential to understanding how gene regulatory networks and ultimately the genotype-to-phenotype map evolve. It is recognized that microRNAs (miRNAs) have the potential to facilitate evolutionary change [1-3]; however, there are no known examples of natural morphological variation caused by evolutionary changes in miRNA expression. Therefore, the contribution of miRNAs to evolutionary change remains unknown [1, 4]. Drosophila melanogaster subgroup species display a portion of trichome-free cuticle on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. simulans [5, 6]. However, naked valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 μm(2). We investigated the genetic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbaby (svb) [7, 8] contributes to this morphological difference. Instead, we show that changes in mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9]. Therefore, our results reveal a novel mechanism for morphological evolution and suggest that modulation of the expression of miRNAs potentially plays a prominent role in generating organismal diversity.
|
| 巻・号 |
23(6)
|
| ページ |
523-8
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| 公開日 |
2013-3-18
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| DOI |
10.1016/j.cub.2013.02.018
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| PII |
S0960-9822(13)00189-9
|
| PMID |
23453955
|
| PMC |
PMC3605577
|
| MeSH |
Animals
Chromosome Mapping
Drosophila melanogaster / anatomy & histology*
Drosophila melanogaster / genetics*
Drosophila melanogaster / growth & development
Drosophila melanogaster / metabolism
Evolution, Molecular*
Extremities / anatomy & histology
Female
Gene Expression Regulation, Developmental*
In Situ Hybridization
Male
MicroRNAs / genetics*
MicroRNAs / metabolism
Pupa / anatomy & histology
Pupa / genetics
Pupa / growth & development
Pupa / metabolism
Quantitative Trait Loci
|
| IF |
9.601
|
| 引用数 |
24
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
st ss e (DGRC#101760) |
