論文 - 詳細
| RRC ID | 22011 |
|---|---|
| 著者 | Lewellyn L, Cetera M, Horne-Badovinac S. |
| タイトル | Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila. |
| ジャーナル | J Cell Biol |
| Abstract |
Complex organ shapes arise from the coordinate actions of individual cells. The Drosophila egg chamber is an organ-like structure that lengthens along its anterior-posterior axis as it grows. This morphogenesis depends on an unusual form of planar polarity in the organ's outer epithelial layer, the follicle cells. Interestingly, this epithelium also undergoes a directed migration that causes the egg chamber to rotate around its anterior-posterior axis. However, the functional relationship between planar polarity and migration in this tissue is unknown. We have previously reported that mutations in the Misshapen kinase disrupt follicle cell planar polarity. Here we show that Misshapen's primary role in this system is to promote individual cell motility. Misshapen decreases integrin levels at the basal surface, which may facilitate detachment of each cell's trailing edge. These data provide mechanistic insight into Misshapen's conserved role in cell migration and suggest that follicle cell planar polarity may be an emergent property of individual cell migratory behaviors within the epithelium. |
| 巻・号 | 200(6) |
| ページ | 721-9 |
| 公開日 | 2013-3-18 |
| DOI | 10.1083/jcb.201209129 |
| PII | jcb.201209129 |
| PMID | 23509067 |
| PMC | PMC3601364 |
| MeSH | Animals Cell Movement / physiology* Cell Polarity / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Epithelial Cells / cytology Epithelial Cells / metabolism* Integrins / genetics Integrins / metabolism* Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* |
| IF | 8.811 |
| 引用数 | 37 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | tj-Gal4 (DGRC#104055) and msn-YFP (DGRC#115454) |