| RRC ID |
30418
|
| 著者 |
Hoshino M, Matsuzaki F, Nabeshima Y, Hama C.
|
| タイトル |
hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein.
|
| ジャーナル |
Neuron
|
| Abstract |
We have identified a gene, hikaru genki (hig), whose mutant phenotype includes abnormal locomotor behavior. Mutant first instar larvae have uncoordinated movements, and both larvae and adults have reduced locomotion. Sequence analyses revealed that this gene encodes a novel type of protein with a signal sequence, but without transmembrane regions. One of its domains has similarities with immunoglobulin domains; three or four regions are similar to a complement-binding domain found in complement-related proteins and selectins. In situ hybridization to embryos revealed that accumulation of the hig transcripts is restricted to subsets of cells in the CNS. Our data suggest that hig has a role in the development of CNS functions involved in locomotor activity.
|
| 巻・号 |
10(3)
|
| ページ |
395-407
|
| 公開日 |
1993-3-1
|
| DOI |
10.1016/0896-6273(93)90329-p
|
| PII |
0896-6273(93)90329-P
|
| PMID |
8461133
|
| MeSH |
Amino Acid Sequence
Animals
Animals, Genetically Modified
Base Sequence
Central Nervous System / cytology
Central Nervous System / physiology*
Chromosome Mapping
Drosophila / embryology
Drosophila / genetics*
Drosophila Proteins*
Embryo, Nonmammalian / metabolism
Gene Expression
Genes, Insect*
Locomotion*
Molecular Sequence Data
Movement Disorders / genetics*
Mutation
Nerve Tissue Proteins / genetics*
RNA, Messenger / metabolism
Sequence Homology, Amino Acid
Transcription, Genetic
|
| IF |
14.415
|
| 引用数 |
34
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
DGRC#109573
DGRC#109581 |
