論文 - 詳細
| RRC ID | 30423 |
|---|---|
| 著者 | Takahashi K, Matsuo T, Katsube T, Ueda R, Yamamoto D. |
| タイトル | Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis. |
| ジャーナル | Mech Dev |
| Abstract |
During Drosophila embryogenesis, the ventral epidermis dorsally expands and the left and right epithelial sheets meet and fuse along the dorsal midline. For this dorsal closure to occur, two PDZ domain proteins, Cno and ZO-1, are required. The dorsal epidermis remains open when the expression of ZO-1 and Cno are reduced simultaneously by hypomorphic mutations in the relevant loci. ZO-1 and Cno colocalize at adherens junctions in embryonic epithelia, and form a protein complex upon binding to each other. Genetic analysis showed that Cno is involved in the Jun N-terminal kinase (JNK) pathway for dorsal closure, as a modulator acting upstream of, or in parallel with, the small GTPase Drac1. The ZO-1-Cno complex may be involved in dynamic changes in cytoskeletal organization and cell adhesion during morphogenetic events associated with dorsal closure in the Drosophila embryo. |
| 巻・号 | 78(1-2) |
| ページ | 97-111 |
| 公開日 | 1998-11-1 |
| DOI | 10.1016/s0925-4773(98)00151-8 |
| PII | S0925-4773(98)00151-8 |
| PMID | 9858699 |
| MeSH | Animals Animals, Genetically Modified Calcium-Calmodulin-Dependent Protein Kinases / physiology* Cell Adhesion / genetics Cytoskeleton / ultrastructure Drosophila Proteins* Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Embryo, Nonmammalian / metabolism Embryo, Nonmammalian / ultrastructure Epidermis / embryology Epidermis / metabolism GTP-Binding Proteins / physiology In Situ Hybridization Insect Proteins / biosynthesis Insect Proteins / genetics Insect Proteins / metabolism Insect Proteins / physiology* JNK Mitogen-Activated Protein Kinases Macromolecular Substances Membrane Proteins / genetics Membrane Proteins / metabolism Membrane Proteins / physiology* Mitogen-Activated Protein Kinases* Morphogenesis / genetics Phosphoproteins / genetics Phosphoproteins / metabolism Phosphoproteins / physiology* Protein Binding Recombinant Fusion Proteins / metabolism Saccharomyces cerevisiae / genetics Zonula Occludens-1 Protein rac GTP-Binding Proteins* |
| IF | 2.126 |
| 引用数 | 79 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#109029 DGRC#109030 DGRC#109032 |