論文 - 詳細
| RRC ID | 30474 |
|---|---|
| 著者 | Kurusu M, Maruyama Y, Adachi Y, Okabe M, Suzuki E, Furukubo-Tokunaga K. |
| タイトル | A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain. |
| ジャーナル | Dev Biol |
| Abstract |
The intrinsic neurons of mushroom bodies (MBs), centers of olfactory learning in the Drosophila brain, are generated by a specific set of neuroblasts (Nbs) that are born in the embryonic stage and exhibit uninterrupted proliferation till the end of the pupal stage. Whereas MB provides a unique model to study proliferation of neural progenitors, the underlying mechanism that controls persistent activity of MB-Nbs is poorly understood. Here we show that Tailless (TLL), a conserved orphan nuclear receptor, is required for optimum proliferation activity and prolonged maintenance of MB-Nbs and ganglion mother cells (GMCs). Mutations of tll progressively impair cell cycle in MB-Nbs and cause premature loss of MB-Nbs in the early pupal stage. TLL is also expressed in MB-GMCs to prevent apoptosis and promote cell cycling. In addition, we show that ectopic expression of tll leads to brain tumors, in which Prospero, a key regulator of progenitor proliferation and differentiation, is suppressed whereas localization of molecular components involved in asymmetric Nb division is unaffected. These results as a whole uncover a distinct regulatory mechanism of self-renewal and differentiation of the MB progenitors that is different from the mechanisms found in other progenitors. |
| 巻・号 | 326(1) |
| ページ | 224-36 |
| 公開日 | 2009-2-1 |
| DOI | 10.1016/j.ydbio.2008.11.013 |
| PII | S0012-1606(08)01359-6 |
| PMID | 19084514 |
| MeSH | Animals Apoptosis / physiology Brain Neoplasms / embryology Brain Neoplasms / genetics Brain Neoplasms / metabolism Cell Differentiation / physiology Cell Proliferation* DNA-Binding Proteins / genetics DNA-Binding Proteins / physiology* Drosophila / embryology* Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Ganglia, Invertebrate / embryology Ganglia, Invertebrate / growth & development Ganglia, Invertebrate / metabolism Mushroom Bodies / embryology* Mushroom Bodies / growth & development* Mushroom Bodies / metabolism Mutation Nerve Tissue Proteins / metabolism Neurons / cytology Neurons / physiology Nuclear Proteins / metabolism Repressor Proteins / genetics Repressor Proteins / physiology* Stem Cells / cytology Stem Cells / physiology Transcription Factors / metabolism |
| IF | 2.896 |
| 引用数 | 41 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#109680 |