RRC ID 32415
著者 Chihara T, Kitabayashi A, Morimoto M, Takeuchi K, Masuyama K, Tonoki A, Davis RL, Wang JW, Miura M.
タイトル Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila.
ジャーナル PLoS Genet
Abstract Sensory and cognitive performance decline with age. Neural dysfunction caused by nerve death in senile dementia and neurodegenerative disease has been intensively studied; however, functional changes in neural circuits during the normal aging process are not well understood. Caspases are key regulators of cell death, a hallmark of age-related neurodegeneration. Using a genetic probe for caspase-3-like activity (DEVDase activity), we have mapped age-dependent neuronal changes in the adult brain throughout the lifespan of Drosophila. Spatio-temporally restricted caspase activation was observed in the antennal lobe and ellipsoid body, brain structures required for olfaction and visual place memory, respectively. We also found that caspase was activated in an age-dependent manner in specific subsets of Drosophila olfactory receptor neurons (ORNs), Or42b and Or92a neurons. These neurons are essential for mediating innate attraction to food-related odors. Furthermore, age-induced impairments of neural transmission and attraction behavior could be reversed by specific inhibition of caspase in these ORNs, indicating that caspase activation in Or42b and Or92a neurons is responsible for altering animal behavior during normal aging.
巻・号 10(6)
ページ e1004437
公開日 2014-6-1
DOI 10.1371/journal.pgen.1004437
PII PGENETICS-D-13-03558
PMID 24967585
PMC PMC4072539
MeSH Aging / genetics Aging / physiology Animals Animals, Genetically Modified Apoptosis / drug effects Behavior, Animal / physiology Brain Mapping Caspase 3 / biosynthesis Caspase 3 / genetics* Chemotaxis / genetics* Dendrites / drug effects Dendrites / genetics Drosophila Proteins Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Malus Olfactory Receptor Neurons* Receptors, Odorant Smell / genetics* Synaptic Transmission / genetics*
IF 5.175
引用数 10
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ DGRC#103945