| RRC ID |
32416
|
| 著者 |
Redt-Clouet C, Trannoy S, Boulanger A, Tokmatcheva E, Savvateeva-Popova E, Parmentier ML, Preat T, Dura JM.
|
| タイトル |
Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila.
|
| ジャーナル |
Eur J Neurosci
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| Abstract |
The remodelling of neurons during their development is considered necessary for their normal function. One fundamental mechanism involved in this remodelling process in both vertebrates and invertebrates is axon pruning. A well-documented case of such neuronal remodelling is the developmental axon pruning of mushroom body γ neurons that occurs during metamorphosis in Drosophila. The γ neurons undergo pruning of larval-specific dendrites and axons at metamorphosis, followed by their regrowth as adult-specific dendrites and axons. We recently revealed a molecular cascade required for this pruning. The nuclear receptor ftz-f1 activates the expression of the steroid hormone receptor EcR-B1, a key component for γ remodelling, and represses expression of Hr39, an ftz-f1 homologous gene. If ectopically expressed in the γ neurons, HR39 inhibits normal pruning, probably by competing with endogenous FTZ-F1, which results in decreased EcR-B1 expression. The mushroom bodies are a bilaterally symmetric structure in the larval and adult brain and are involved in the processing of different types of olfactory memory. How memory is affected in pruning-deficient adult flies that possess larval-stage neuronal circuitry will help to explain the functional role of neuron remodelling. Flies overexpressing Hr39 are viable as adults and make it possible to assess the requirement for wild-type mushroom body pruning in memory. While blocking mushroom body neuron remodelling impaired memory after short-term courtship conditioning, long-term memory was normal. These results show that larval pruning is necessary for adult memory and that expression of courtship short-term memory and long-term memory may be parallel and independent.
|
| 巻・号 |
35(11)
|
| ページ |
1684-91
|
| 公開日 |
2012-6-1
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| DOI |
10.1111/j.1460-9568.2012.08103.x
|
| PMID |
22571719
|
| MeSH |
Animals
Cell Differentiation / physiology*
Drosophila melanogaster / cytology
Drosophila melanogaster / growth & development*
Drosophila melanogaster / physiology
Female
Male
Memory, Long-Term / physiology*
Mushroom Bodies / cytology
Mushroom Bodies / growth & development*
Mushroom Bodies / physiology
Neuronal Plasticity / physiology*
Neurons / cytology
Neurons / physiology
Sexual Behavior, Animal / physiology*
|
| IF |
3.115
|
| 引用数 |
10
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
DGRC#202206 |
