| RRC ID |
36255
|
| 著者 |
Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S.
|
| タイトル |
Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Tissues use numerous mechanisms to change shape during development. The Drosophila egg chamber is an organ-like structure that elongates to form an elliptical egg. During elongation the follicular epithelial cells undergo a collective migration that causes the egg chamber to rotate within its surrounding basement membrane. Rotation coincides with the formation of a 'molecular corset', in which actin bundles in the epithelium and fibrils in the basement membrane are all aligned perpendicular to the elongation axis. Here we show that rotation plays a critical role in building the actin-based component of the corset. Rotation begins shortly after egg chamber formation and requires lamellipodial protrusions at each follicle cell's leading edge. During early stages, rotation is necessary for tissue-level actin bundle alignment, but it becomes dispensable after the basement membrane is polarized. This work highlights how collective cell migration can be used to build a polarized tissue organization for organ morphogenesis.
|
| 巻・号 |
5
|
| ページ |
5511
|
| 公開日 |
2014-11-21
|
| DOI |
10.1038/ncomms6511
|
| PII |
ncomms6511
|
| PMID |
25413675
|
| PMC |
PMC4241503
|
| MeSH |
Actins
Animals
Cadherins / genetics
Carrier Proteins / genetics
Cell Movement
Cell Polarity
Contractile Proteins / metabolism*
Drosophila Proteins / genetics
Drosophila melanogaster / embryology*
Eye Proteins / genetics
Homeodomain Proteins / genetics
Microfilament Proteins / genetics
Morphogenesis
Oogenesis / genetics*
Ovum / growth & development*
Pseudopodia / metabolism*
RNA Interference
RNA, Small Interfering
Transcription Factors / genetics
|
| IF |
12.121
|
| 引用数 |
92
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
DGRC#104055 |
