| RRC ID |
36307
|
| 著者 |
Ray RP, Matamoro-Vidal A, Ribeiro PS, Tapon N, Houle D, Salazar-Ciudad I, Thompson BJ.
|
| タイトル |
Patterned Anchorage to the Apical Extracellular Matrix Defines Tissue Shape in the Developing Appendages of Drosophila.
|
| ジャーナル |
Dev Cell
|
| Abstract |
How tissues acquire their characteristic shape is a fundamental unresolved question in biology. While genes have been characterized that control local mechanical forces to elongate epithelial tissues, genes controlling global forces in epithelia have yet to be identified. Here, we describe a genetic pathway that shapes appendages in Drosophila by defining the pattern of global tensile forces in the tissue. In the appendages, shape arises from tension generated by cell constriction and localized anchorage of the epithelium to the cuticle via the apical extracellular-matrix protein Dumpy (Dp). Altering Dp expression in the developing wing results in predictable changes in wing shape that can be simulated by a computational model that incorporates only tissue contraction and localized anchorage. Three other wing shape genes, narrow, tapered, and lanceolate, encode components of a pathway that modulates Dp distribution in the wing to refine the global force pattern and thus wing shape.
|
| 巻・号 |
34(3)
|
| ページ |
310-22
|
| 公開日 |
2015-8-10
|
| DOI |
10.1016/j.devcel.2015.06.019
|
| PII |
S1534-5807(15)00426-8
|
| PMID |
26190146
|
| PMC |
PMC4539345
|
| MeSH |
Animals
Body Patterning*
Cell Adhesion
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / embryology*
Epithelium / metabolism*
Extracellular Matrix / metabolism
Extracellular Matrix Proteins / genetics
Extracellular Matrix Proteins / metabolism*
Gene Expression Regulation, Developmental
Ion Channels / metabolism
Protein Structure, Tertiary
RNA Interference
RNA, Small Interfering
Signal Transduction / genetics
Wings, Animal / embryology*
|
| IF |
10.092
|
| 引用数 |
43
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
DGRC#115238 |
