RRC ID 57102
著者 Tian A, Duwadi D, Benchabane H, Ahmed Y.
タイトル Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.
ジャーナル PLoS Genet
Abstract Signal transduction activated by Wingless/Wnt ligands directs cell proliferation and fate specification in metazoans, and its overactivation underlies the development of the vast majority of colorectal cancers. In the conventional model, the secretion and movement of Wingless to cells distant from its source of synthesis are essential for long-range signaling in tissue patterning. However, this model was upended recently by an unanticipated finding: replacement of wild-type Drosophila Wingless with a membrane-tethered form produced viable adults with largely normal external morphology, which suggested that Wingless secretion and movement are dispensable for tissue patterning. Herein, we tested this foundational principle in the adult intestine, where Wingless signaling gradients coincide with all major boundaries between compartments. We find that the critical roles of Wingless during adult intestinal development, which include regulation of target gene activation, boundary formation, stem cell proliferation, epithelial cell fate specification, muscle differentiation, gut folding, and signaling crosstalk with the Decapentaplegic pathway, are all disrupted by Wingless tethering. These findings provide new evidence that supports the requirement for the direct, long-range action of Wingless in tissue patterning, with relevance for animal development, tissue homeostasis and Wnt-driven disease.
巻・号 15(6)
ページ e1008111
公開日 2019-6-1
DOI 10.1371/journal.pgen.1008111
PII PGENETICS-D-18-01420
PMID 31194729
PMC PMC6563961
MeSH Animals Body Patterning / genetics* Cell Differentiation / genetics Cell Lineage / genetics Cell Proliferation / genetics Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Epithelial Cells / cytology Epithelial Cells / metabolism Gene Expression Regulation, Developmental / genetics Homeostasis Intestines / growth & development Signal Transduction / genetics Stem Cells / metabolism Wnt1 Protein / genetics*
IF 5.224
引用数 7
リソース情報
ショウジョウバエ DGRC#113273