| RRC ID |
57109
|
| 著者 |
Boto T, Stahl A, Zhang X, Louis T, Tomchik SM.
|
| タイトル |
Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Dopaminergic neurons play a key role in encoding associative memories, but little is known about how these circuits modulate memory strength. Here we report that different sets of dopaminergic neurons projecting to the Drosophila mushroom body (MB) differentially regulate valence and memory strength. PPL2 neurons increase odor-evoked calcium responses to a paired odor in the MB and enhance behavioral memory strength when activated during olfactory classical conditioning. When paired with odor alone, they increase MB responses to the paired odor but do not drive behavioral approach or avoidance, suggesting that they increase the salience of the odor without encoding strong valence. This contrasts with the role of dopaminergic PPL1 neurons, which drive behavioral reinforcement but do not alter odor-evoked calcium responses in the MB when stimulated. These data suggest that different sets of dopaminergic neurons modulate olfactory valence and memory strength via independent actions on a memory-encoding brain region.
|
| 巻・号 |
27(7)
|
| ページ |
2014-2021.e2
|
| 公開日 |
2019-5-14
|
| DOI |
10.1016/j.celrep.2019.04.069
|
| PII |
S2211-1247(19)30542-X
|
| PMID |
31091441
|
| PMC |
PMC6585410
|
| MeSH |
Animals
Dopaminergic Neurons / cytology
Dopaminergic Neurons / metabolism*
Drosophila melanogaster
Memory / physiology*
Mushroom Bodies / cytology
Mushroom Bodies / metabolism*
Neuronal Plasticity / physiology*
|
| IF |
7.815
|
| 引用数 |
6
|
| リソース情報 |
| ショウジョウバエ |
DGRC#113066
DGRC#105062 |
