| RRC ID |
57110
|
| 著者 |
Bielopolski N, Amin H, Apostolopoulou AA, Rozenfeld E, Lerner H, Huetteroth W, Lin AC, Parnas M.
|
| タイトル |
Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila.
|
| ジャーナル |
Elife
|
| Abstract |
Olfactory associative learning in Drosophila is mediated by synaptic plasticity between the Kenyon cells of the mushroom body and their output neurons. Both Kenyon cells and their inputs from projection neurons are cholinergic, yet little is known about the physiological function of muscarinic acetylcholine receptors in learning in adult flies. Here, we show that aversive olfactory learning in adult flies requires type A muscarinic acetylcholine receptors (mAChR-A), particularly in the gamma subtype of Kenyon cells. mAChR-A inhibits odor responses and is localized in Kenyon cell dendrites. Moreover, mAChR-A knockdown impairs the learning-associated depression of odor responses in a mushroom body output neuron. Our results suggest that mAChR-A function in Kenyon cell dendrites is required for synaptic plasticity between Kenyon cells and their output neurons.
|
| 巻・号 |
8
|
| 公開日 |
2019-6-19
|
| DOI |
10.7554/eLife.48264
|
| PII |
48264
|
| PMID |
31215865
|
| PMC |
PMC6641838
|
| MeSH |
Aging / physiology*
Animals
Behavior, Animal / drug effects
Drosophila Proteins / genetics
Drosophila Proteins / physiology*
Drosophila melanogaster / cytology
Drosophila melanogaster / drug effects
Drosophila melanogaster / physiology*
Learning*
Muscarine / pharmacology
Muscarinic Agonists / pharmacology
Mushroom Bodies / cytology
Mushroom Bodies / drug effects
Mushroom Bodies / physiology
Mutation / genetics
Odorants
Receptors, Muscarinic / genetics
Receptors, Muscarinic / physiology*
Smell / drug effects
Smell / physiology*
|
| IF |
7.551
|
| 引用数 |
3
|
| リソース情報 |
| ショウジョウバエ |
DGRC#104266 |
