| RRC ID |
59102
|
| 著者 |
Li Y, Zhang F, Jiang N, Liu T, Shen J, Zhang J.
|
| タイトル |
Decapentaplegic signaling regulates Wingless ligand production and target activation during Drosophila wing development.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
The Decapentaplegic (Dpp) and Wingless (Wg) signaling pathways are essential for animal development. However, how these two signals are integrated in distinct tissues is not fully understood. Here, we describe a novel mode of Dpp-Wg crosstalk during Drosophila wing development. We show that the canonical Dpp signaling is required for Wg target gene activation. In addition, Dpp signaling inhibits the transcription of wg through the schnurri (shn) repressor complex. A Dpp-responsive shn/pMad/Med silencer element (SSE) is identified in the genomic loci of the wg gene. ChIP analysis suggests that shn interacts with this element in vivo. Our findings support a model in which Dpp signaling plays a dual role in transcriptional regulation of both the wg gene and downstream targets.
|
| 巻・号 |
594(7)
|
| ページ |
1176-1186
|
| 公開日 |
2020-4-1
|
| DOI |
10.1002/1873-3468.13713
|
| PMID |
31814119
|
| MeSH |
Animals
Drosophila Proteins / biosynthesis
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / genetics
Drosophila melanogaster / growth & development
Drosophila melanogaster / metabolism*
Gene Expression Regulation, Developmental
Ligands
Signal Transduction*
Transcription, Genetic
Wings, Animal / growth & development*
Wings, Animal / metabolism*
Wnt1 Protein / biosynthesis
Wnt1 Protein / genetics
Wnt1 Protein / metabolism*
|
| IF |
3.057
|
| 引用数 |
0
|
| リソース情報 |
| ショウジョウバエ |
DGRC#111141
DGRC#114393
DGRC#120640 |
