RRC ID 59181
著者 Blanco-Obregon D, Katz MJ, Durrieu L, Gándara L, Wappner P.
タイトル Context-specific functions of Notch in Drosophila blood cell progenitors.
ジャーナル Dev Biol
Abstract Drosophila Larval hematopoiesis takes place at the lymph gland, where myeloid-like progenitors differentiate into Plasmatocytes and Crystal Cells, under regulation of conserved signaling pathways. It has been established that the Notch pathway plays a specific role in Crystal Cell differentiation and maintenance. In mammalian hematopoiesis, the Notch pathway has been proposed to fulfill broader functions, including Hematopoietic Stem Cell maintenance and cell fate decision in progenitors. In this work we describe different roles that Notch plays in the lymph gland. We show that Notch, activated by its ligand Serrate, expressed at the Posterior Signaling Center, is required to restrain Core Progenitor differentiation. We define a novel population of blood cell progenitors that we name Distal Progenitors, where Notch, activated by Serrate expressed in Lineage Specifying Cells at the Medullary Zone/Cortical Zone boundary, regulates a binary decision between Plasmatocyte and Crystal Cell fates. Thus, Notch plays context-specific functions in different blood cell progenitor populations of the Drosophila lymph gland.
巻・号 462(1)
ページ 101-115
公開日 2020-6-1
DOI 10.1016/j.ydbio.2020.03.018
PII S0012-1606(20)30106-8
PMID 32243888
MeSH Animals Blood Cells / cytology Cell Differentiation / physiology Cell Lineage Drosophila Proteins / metabolism Drosophila Proteins / physiology Drosophila melanogaster / metabolism Hematopoiesis / physiology Hematopoietic Stem Cells / cytology* Jagged-1 Protein / metabolism Larva / metabolism Lymph Nodes / metabolism* Receptors, Notch / metabolism* Receptors, Notch / physiology Signal Transduction / physiology
IF 2.896
引用数 0
リソース情報
ショウジョウバエ DGRC#105442