RRC ID |
70810
|
著者 |
Tseng CY, Burel M, Cammer M, Harsh S, Flaherty MS, Baumgartner S, Bach EA.
|
タイトル |
chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche.
|
ジャーナル |
Dev Cell
|
Abstract |
Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. Surprisingly, chinmo-/- GSCs rely on a new mechanism of competition in which they secrete the extracellular matrix protein Perlecan to selectively evict non-mutant GSCs and then upregulate Perlecan-binding proteins to remain in the altered niche. Over time, the GSC pool can be entirely replaced with chinmo-/- cells. As a consequence, the mutant chinmo allele acts as a gene drive element; the majority of offspring inherit the allele despite the heterozygous genotype of the parent. Our results suggest that the influence of GSC competition may extend beyond individual stem cell niche dynamics to population-level allelic drift and evolution.
|
巻・号 |
57(1)
|
ページ |
80-94.e7
|
公開日 |
2022-1-10
|
DOI |
10.1016/j.devcel.2021.12.004
|
PII |
S1534-5807(21)00993-X
|
PMID |
34942115
|
PMC |
PMC8752517
|
MeSH |
Adult Germline Stem Cells / metabolism
Adult Germline Stem Cells / physiology*
Animals
Cell Differentiation / physiology
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / metabolism
Extracellular Matrix / metabolism
Gene Expression / genetics
Gene Expression Regulation, Developmental / genetics
Germ Cells / metabolism
Heparan Sulfate Proteoglycans / metabolism
Male
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Signal Transduction / physiology
Stem Cell Niche / genetics
Stem Cell Niche / physiology
Testis / metabolism
Transcription Factors / metabolism
|
IF |
10.092
|
リソース情報 |
ショウジョウバエ |
DGRC#111100
DGRC#104055 |