論文 - 詳細
| RRC ID | 77469 |
|---|---|
| 著者 | Stinchfield MJ, Weasner BP, Weasner BM, Zhitomersky D, Kumar JP, O'Connor MB, Newfeld SJ. |
| タイトル | Fourth Chromosome Resource Project: a comprehensive resource for genetic analysis in Drosophila that includes humanized stocks. |
| ジャーナル | Genetics |
| Abstract |
The 4th chromosome is the final frontier for genetic analysis in Drosophila. Small, heterochromatic and devoid of recombination the 4th has long been ignored. Nevertheless, its long arm contains 79 protein coding genes. The Fourth Chromosome Resource Project (FCRP) has a goal of facilitating the investigation of genes on this neglected chromosome. The project has 446 stocks publicly available at the Bloomington and Kyoto stock centers with phenotypic data curated by the FlyBase and FlyPush resources. Four of the five stock sets are nearly complete: 1) UAS.fly cDNAs, 2) UAS.human homolog cDNAs, 3) gene trap mutants and protein traps, plus 4) stocks promoting meiotic and mitotic recombination on the 4th. Ongoing is mutagenesis of each 4th gene on a new FRT bearing chromosome for marked single cell clones. Beyond flies, FCRP facilitates the creation and analysis of humanized fly stocks. These provide opportunities to apply Drosophila genetics to the analysis of human gene interaction and function. In addition, the FCRP provides investigators with confidence through stock validation and an incentive via phenotyping to tackle genes on the 4th that have never been studied. Taken together, FCRP stocks will facilitate all manner of genetic and molecular studies. The resource is readily available to researchers to enhance our understanding of metazoan biology, including conserved molecular mechanisms underlying health and disease. |
| 公開日 | 2023-11-20 |
| DOI | 10.1093/genetics/iyad201 |
| PII | 7429096 |
| PMID | 37981656 |
| IF | 4.015 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119021 DGRC#119022 DGRC#119023 DGRC#119024 DGRC#118741 DGRC#118742 DGRC#118743 DGRC#118744 DGRC#118745 DGRC#118746 DGRC#118747 DGRC#118748 DGRC#118749 DGRC#118750 DGRC#118751 DGRC#118752 DGRC#118753 DGRC#118754 DGRC#118755 DGRC#118756 DGRC#118757 DGRC#118758 DGRC#118759 DGRC#118760 DGRC#118761 DGRC#118762 DGRC#118763 DGRC#118764 DGRC#118765 DGRC#118766 DGRC#118767 DGRC#118768 DGRC#118769 DGRC#118770 DGRC#118771 DGRC#118772 DGRC#118773 DGRC#118774 DGRC#118775 DGRC#118776 DGRC#118777 DGRC#118778 DGRC#118779 DGRC#118780 DGRC#118781 DGRC#118782 DGRC#118783 DGRC#118784 DGRC#118785 DGRC#118786 DGRC#118787 DGRC#118788 DGRC#118789 DGRC#118839 DGRC#118840 DGRC#118841 DGRC#118842 DGRC#118843 DGRC#118844 DGRC#118845 DGRC#118846 DGRC#118847 DGRC#118848 DGRC#118849 DGRC#118850 DGRC#118851 DGRC#118852 DGRC#118853 DGRC#118854 DGRC#118855 DGRC#118856 DGRC#118857 DGRC#118858 DGRC#118859 DGRC#118860 DGRC#118861 DGRC#118862 DGRC#118863 DGRC#118864 DGRC#118865 DGRC#118866 DGRC#118867 DGRC#118868 DGRC#118869 DGRC#118870 DGRC#118871 DGRC#118872 DGRC#118873 DGRC#118874 DGRC#118875 DGRC#118876 DGRC#118877 DGRC#118878 DGRC#118879 DGRC#118880 DGRC#118881 DGRC#118882 DGRC#118883 DGRC#118884 DGRC#118885 DGRC#118886 DGRC#118887 DGRC#118888 DGRC#118889 DGRC#118890 DGRC#118891 DGRC#118892 DGRC#118893 DGRC#118894 DGRC#118895 DGRC#118896 DGRC#118897 DGRC#118898 DGRC#118899 DGRC#118900 DGRC#118901 DGRC#118902 DGRC#118903 DGRC#118904 DGRC#118905 DGRC#118906 DGRC#118907 DGRC#118908 DGRC#118909 DGRC#118910 DGRC#118911 DGRC#118912 DGRC#118913 DGRC#118914 DGRC#118915 DGRC#119007 DGRC#119008 DGRC#119009 DGRC#119010 DGRC#119011 DGRC#119012 DGRC#119013 DGRC#119014 DGRC#119015 DGRC#119016 DGRC#119017 DGRC#119018 DGRC#119019 DGRC#119020 |