RRC ID 48857
著者 Herzmann S, Krumkamp R, Rode S, Kintrup C, Rumpf S.
タイトル PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila.
ジャーナル EMBO J
Abstract Pruning of unspecific neurites is an important mechanism during neuronal morphogenesis. Drosophila sensory neurons prune their dendrites during metamorphosis. Pruning dendrites are severed in their proximal regions. Prior to severing, dendritic microtubules undergo local disassembly, and dendrites thin extensively through local endocytosis. Microtubule disassembly requires a katanin homologue, but the signals initiating microtubule breakdown are not known. Here, we show that the kinase PAR-1 is required for pruning and dendritic microtubule breakdown. Our data show that neurons lacking PAR-1 fail to break down dendritic microtubules, and PAR-1 is required for an increase in neuronal microtubule dynamics at the onset of metamorphosis. Mammalian PAR-1 is a known Tau kinase, and genetic interactions suggest that PAR-1 promotes microtubule breakdown largely via inhibition of Tau also in Drosophila Finally, PAR-1 is also required for dendritic thinning, suggesting that microtubule breakdown might precede ensuing plasma membrane alterations. Our results shed light on the signaling cascades and epistatic relationships involved in neurite destabilization during dendrite pruning.
巻・号 36(13)
ページ 1981-1991
公開日 2017-7-3
DOI 10.15252/embj.201695890
PII embj.201695890
PMID 28554895
PMC PMC5494467
MeSH Animals Drosophila / physiology* Drosophila Proteins / metabolism* Epistasis, Genetic Glycogen Synthase Kinase 3 / metabolism* Microtubules / metabolism* Neuronal Plasticity* Signal Transduction
IF 9.889
引用数 16
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ 5055R‐1