RRC ID 42565
著者 Samson WK, Taylor MM.
タイトル Prolactin releasing peptide (PrRP): an endogenous regulator of cell growth.
ジャーナル Peptides
Abstract Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activates stress hormone secretion. Here, we confirm the presence of immunoreactive PrRP in a pheochromocytoma-derived cell line (PC-12) and the ability of exogenous PrRP to stimulate adenylyl cyclase activity in these cultures. Our novel findings are that PrRP stimulated PC-12 cell growth. Furthermore, a role for endogenous PrRP in PC-12 cell growth is suggested by our observations that antisense oligonucleotides and small interfering RNA molecules, which decrease peptide content in these cells, also decrease thymidine incorporation, suggesting an autocrine action of the peptide.
巻・号 27(5)
ページ 1099-103
公開日 2006-5-1
DOI 10.1016/j.peptides.2006.01.008
PII S0196-9781(06)00054-4
PMID 16500730
MeSH Adenylyl Cyclases / metabolism Animals Cell Proliferation / drug effects Oligonucleotides, Antisense / pharmacology PC12 Cells RNA, Small Interfering / pharmacology Rats Thymidine / metabolism Thyrotropin-Releasing Hormone / physiology*
IF 2.843
引用数 9
WOS 分野 PHARMACOLOGY & PHARMACY BIOCHEMISTRY & MOLECULAR BIOLOGY ENDOCRINOLOGY & METABOLISM
リソース情報
ヒト・動物細胞 PC-12(RCB0009)