RRC ID 49290
著者 Ku HY, Sun YH.
タイトル Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna.
ジャーナル PLoS Genet
Abstract Compartment boundary formation plays an important role in development by separating adjacent developmental fields. Drosophila imaginal discs have proven valuable for studying the mechanisms of boundary formation. We studied the boundary separating the proximal A1 segment and the distal segments, defined respectively by Lim1 and Dll expression in the eye-antenna disc. Sharp segregation of the Lim1 and Dll expression domains precedes activation of Notch at the Dll/Lim1 interface. By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold. Disruption of Notch signaling or the actomyosin network reduces apical constriction and epithelial fold, so that Dll and Lim1 cells become intermingled. Our results demonstrate a new mechanism of boundary formation by actomyosin-dependent tissue folding, which provides a physical barrier to prevent mixing of cells from adjacent developmental fields.
巻・号 13(7)
ページ e1006898
公開日 2017-7-1
DOI 10.1371/journal.pgen.1006898
PII PGENETICS-D-17-00090
PMID 28708823
PMC PMC5533456
MeSH Animals Arthropod Antennae / growth & development* Cloning, Molecular Drosophila / embryology Drosophila / genetics* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Epithelial Cells / metabolism Gene Expression Regulation, Developmental Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Image Processing, Computer-Assisted LIM-Homeodomain Proteins / genetics LIM-Homeodomain Proteins / metabolism* MicroRNAs / genetics MicroRNAs / metabolism Protein Folding Receptors, Notch / genetics Receptors, Notch / metabolism* Signal Transduction Transcription Factors / genetics Transcription Factors / metabolism* Wings, Animal / growth & development
IF 5.175
引用数 1
リソース情報
ショウジョウバエ 3936-R2