RRC ID 45794
著者 Luo J, Xu Z, Tan Z, Zhang Z, Ma L.
タイトル Neuropeptide receptors NPR-1 and NPR-2 regulate Caenorhabditis elegans avoidance response to the plant stress hormone methyl salicylate.
ジャーナル Genetics
Abstract Methyl salicylate (MeSa) is a stress hormone released by plants under attack by pathogens or herbivores . MeSa has been shown to attract predatory insects of herbivores and repel pests. The molecules and neurons underlying animal response to MeSa are not known. Here we found that the nematode Caenorhabditis elegans exhibits a strong avoidance response to MeSa, which requires the activities of two closely related neuropeptide receptors NPR-1 and NPR-2. Molecular analyses suggest that NPR-1 expressed in the RMG inter/motor neurons is required for MeSa avoidance. An NPR-1 ligand FLP-18 is also required. Using a rescuing npr-2 promoter to drive a GFP transgene, we identified that NPR-2 is expressed in multiple sensory and interneurons. Genetic rescue experiments suggest that NPR-2 expressed in the AIZ interneurons is required for MeSa avoidance. We also provide evidence that the AWB sensory neurons might act upstream of RMGs and AIZs to detect MeSa. Our results suggest that NPR-2 has an important role in regulating animal behavior and that NPR-1 and NPR-2 act on distinct interneurons to affect C. elegans avoidance response to MeSa.
巻・号 199(2)
ページ 523-31
公開日 2015-2-1
DOI 10.1534/genetics.114.172239
PII genetics.114.172239
PMID 25527285
PMC PMC4317659
MeSH Animals Behavior, Animal / drug effects* Caenorhabditis elegans / drug effects* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Gene Expression Profiling Gene Expression Regulation / drug effects Interneurons / drug effects Interneurons / metabolism Male Neurons / drug effects Neurons / metabolism Plant Growth Regulators / pharmacology* Salicylates / pharmacology* Sensory Receptor Cells / drug effects Sensory Receptor Cells / metabolism Stress, Physiological*
IF 4.015
引用数 5
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm1583 tm1652