RRC ID 52519
著者 Ohnishi Y, Yasui H, Nozaki M, Nakajima M.
タイトル Molecularly-targeted therapy for the oral cancer stem cells.
ジャーナル Jpn Dent Sci Rev
Abstract Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer. In this review, cetuximab and lapatinib-resistant oral squamous cell carcinoma (OSCC) cells proliferation and migration signal transduction passway is discussed by introducing our research.
巻・号 54(2)
ページ 88-103
公開日 2018-5-1
DOI 10.1016/j.jdsr.2017.11.001
PII S1882-7616(17)30042-X
PMID 29755619
PMC PMC5944082
引用数 1
リソース情報
ヒト・動物細胞 HSC-3(RCB1975) HSC-4(RCB1902) SAS(RCB1974)