RRC ID |
34466
|
著者 |
Kasakura K, Takahashi K, Itoh T, Hosono A, Momose Y, Itoh K, Nishiyama C, Kaminogawa S.
|
タイトル |
Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
The intestine harbors a substantial number of commensal bacteria that provide considerable benefits to the host. Epidemiologic studies have identified associations between alterations in the composition of the intestinal microbiota and the development of allergic disease. However, the cellular and molecular mechanisms underlying these effects remain to be determined. Here, we show that heat-killed commensal bacteria suppressed degranulation of mast cells in vitro in a MyD88-independent manner. In particular, Enterococcus faecalis showed the strongest suppression of degranulation through partial inhibition of Ca(2+) signaling upon the high affinity IgE receptor (FcεRI) cross-linking.
|
巻・号 |
78(10)
|
ページ |
1669-76
|
公開日 |
2014-1-1
|
DOI |
10.1080/09168451.2014.930327
|
PMID |
25273132
|
MeSH |
Animals
Cell Degranulation*
Enterococcus faecalis / physiology*
Female
Intracellular Space / metabolism
Mast Cells / cytology*
Mice
Myeloid Differentiation Factor 88 / metabolism*
Signal Transduction
|
IF |
1.516
|
引用数 |
11
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
一般微生物 |
JCM 1649
JCM 5824
JCM 5826
JCM 5827 |