RRC ID 33300
著者 Eradath MK, Mogami T, Wang G, Tanaka K.
タイトル Time context of cue-outcome associations represented by neurons in perirhinal cortex.
ジャーナル J Neurosci
Abstract The perirhinal cortex (PRh), which has extensive connections with diverse brain sites, may contribute to semantic memory by associating various types of information about objects. However, the extent of the types of associations in which PRh participates is unknown. In the present study, we let monkeys experience a consistent contingency between visual cues and different types of outcomes (water reward and sound-only acknowledgment) in a particular time context for many days and then recorded neuronal activities from PRh and area TE, which is the major source of visual inputs to PRh. We found that PRh cells represented the outcome type in their responses to the visual cues only in the time context in which the monkeys had experienced the cue-outcome contingency. In contrast, TE cells represented the outcome information whenever the cue appeared (i.e., independently from the related time context). These results showed that PRh cells represented not only the cue-outcome contingency but also the time context in which the monkeys had experienced the contingency. We conclude that PRh is not specific to the representation of sensory and associative properties of objects themselves but may represent broader information about objects, including the time context in which the objects are associated with particular outcomes.
巻・号 35(10)
ページ 4350-65
公開日 2015-3-11
DOI 10.1523/JNEUROSCI.4730-14.2015
PII 35/10/4350
PMID 25762680
PMC PMC4355203
MeSH Action Potentials / physiology* Analysis of Variance Animals Association Learning / physiology* Attention / physiology Cerebral Cortex / cytology* Cues* Macaca mulatta Male Neurons / physiology* Photic Stimulation Reaction Time Reward*
IF 5.674
引用数 14
WOS 分野 NEUROSCIENCES
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