RRC ID 48028
著者 Nishi E, Tsutsui K, Imai H.
タイトル High maltose sensitivity of sweet taste receptors in the Japanese macaque (Macaca fuscata).
ジャーナル Sci Rep
Abstract Taste sensitivity differs among animal species depending on feeding habitat. To humans, sucrose is one of the sweetest natural sugars, and this trait is expected to be similar in other primates. However, previous behavioral tests have shown that some primate species have equal preferences for maltose and sucrose. Because sweet tastes are recognized when compounds bind to the sweet taste receptor Tas1R2/Tas1R3, we evaluated the responses of human and Japanese macaque Tas1R2/Tas1R3 to various natural sugars using a heterologous expression system. Human Tas1R2/Tas1R3 showed high sensitivity to sucrose, as expected; however, Japanese macaque Tas1R2/Tas1R3 showed equally high sensitivity to maltose and sucrose. Furthermore, Japanese macaques showed equally high sensitivity to sucrose and maltose in a two-bottle behavioral experiment. These results indicate that Japanese macaques have high sensitivity to maltose, and this sensitivity is directly related to Tas1R2/Tas1R3 function. This is the first molecular biological evidence that for some primate species, sucrose is not the most preferable natural sugar, as it is for humans.
巻・号 6
ページ 39352
公開日 2016-12-16
DOI 10.1038/srep39352
PII srep39352
PMID 27982108
PMC PMC5159886
MeSH Animals Humans Macaca / physiology* Maltose / metabolism* Receptors, G-Protein-Coupled / agonists* Sucrose / metabolism Taste Threshold*
IF 3.998
引用数 4
WOS 分野 NEUROSCIENCES
リソース情報
ニホンザル