RRC ID 47464
著者 Tajiri R, Ogawa N, Fujiwara H, Kojima T.
タイトル Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster.
ジャーナル PLoS Genet
Abstract Body shapes are much more variable than body plans. One way to alter body shapes independently of body plans would be to mechanically deform bodies. To what extent body shapes are regulated physically, or molecules involved in physical control of morphogenesis, remain elusive. During fly metamorphosis, the cuticle (exoskeleton) covering the larval body contracts longitudinally and expands laterally to become the ellipsoidal pupal case (puparium). Here we show that Drosophila melanogaster Obstructor-E (Obst-E) is a protein constituent of the larval cuticle that confers the oriented contractility/expandability. In the absence of obst-E function, the larval cuticle fails to undergo metamorphic shape change and finally becomes a twiggy puparium. We present results indicating that Obst-E regulates the arrangement of chitin, a long-chain polysaccharide and a central component of the insect cuticle, and directs the formation of supracellular ridges on the larval cuticle. We further show that Obst-E is locally required for the oriented shape change of the cuticle during metamorphosis, which is associated with changes in the morphology of those ridges. Thus, Obst-E dramatically affects the body shape in a direct, physical manner by controlling the mechanical property of the exoskeleton.
巻・号 13(1)
ページ e1006548
公開日 2017-1-1
DOI 10.1371/journal.pgen.1006548
PII PGENETICS-D-16-01339
PMID 28076349
PMC PMC5226733
MeSH Animals Body Size / genetics* Carrier Proteins / genetics* Carrier Proteins / metabolism Chitin / genetics Chitin / metabolism Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Metamorphosis, Biological / genetics*
IF 5.175
引用数 14
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ 11142R-1