RRC ID 47667
著者 Sahu A, Ghosh R, Deshpande G, Prasad M.
タイトル A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis.
ジャーナル PLoS Genet
Abstract Intercellular communication mediated by gap junction (GJ) proteins is indispensable during embryogenesis, tissue regeneration and wound healing. Here we report functional analysis of a gap junction protein, Innexin 2 (Inx2), in cell type specification during Drosophila oogenesis. Our data reveal a novel involvement of Inx2 in the specification of Border Cells (BCs), a migratory cell type, whose identity is determined by the cell autonomous STAT activity. We show that Inx2 influences BC fate specification by modulating STAT activity via Domeless receptor endocytosis. Furthermore, detailed experimental analysis has uncovered that Inx2 also regulates a calcium flux that transmits across the follicle cells. We propose that Inx2 mediated calcium flux in the follicle cells stimulates endocytosis by altering Dynamin (Shibire) distribution which is in turn critical for careful calibration of STAT activation and, thus for BC specification. Together our data provide unprecedented molecular insights into how gap junction proteins can regulate cell-type specification.
巻・号 13(1)
ページ e1006542
公開日 2017-1-1
DOI 10.1371/journal.pgen.1006542
PII PGENETICS-D-16-01313
PMID 28114410
PMC PMC5256874
MeSH Animals Calcium / metabolism* Connexins / genetics Connexins / metabolism* Drosophila / genetics* Drosophila / growth & development Drosophila Proteins / genetics Drosophila Proteins / metabolism* Dynamins / genetics Dynamins / metabolism Endocytosis Female Oogenesis* Ovarian Follicle / cytology Ovarian Follicle / metabolism Receptors, Interleukin / genetics Receptors, Interleukin / metabolism STAT Transcription Factors / genetics STAT Transcription Factors / metabolism
IF 5.175
引用数 9
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ DGRC#111858 DGRC#114609