RRC ID 45309
著者 Tang Y, Abe N, Yoshimoto M, Zhu B, Murata Y, Nakamura Y.
タイトル Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells.
ジャーナル Biosci Biotechnol Biochem
Abstract An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium ionophore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogen-activated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
巻・号 79(1)
ページ 159-63
公開日 2015-1-1
DOI 10.1080/09168451.2014.963503
PMID 25253661
MeSH Anti-Allergic Agents / pharmacology* Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Basophils / drug effects* Basophils / immunology Basophils / pathology Calcimycin / antagonists & inhibitors Calcimycin / pharmacology Calcium Ionophores / pharmacology Cell Line Gene Expression Regulation Humans Interleukin-13 / antagonists & inhibitors Interleukin-13 / genetics Interleukin-13 / immunology Isothiocyanates / pharmacology* NF-kappa B / antagonists & inhibitors NF-kappa B / genetics NF-kappa B / immunology NFATC Transcription Factors / antagonists & inhibitors NFATC Transcription Factors / genetics NFATC Transcription Factors / immunology Phosphorylation / drug effects Signal Transduction p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / immunology
IF 1.516
引用数 5
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 KU812(RCB0495)