RRC ID 52130
著者 Go S, Go S, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.
タイトル Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.
ジャーナル J Biol Chem
Abstract Gangliosides (sialic acid-containing glycosphingolipids) help regulate many important biological processes, including cell proliferation, signal transduction, and differentiation, via formation of functional microdomains in plasma membranes. The structural diversity of gangliosides arises from both the ceramide moiety and glycan portion. Recently, differing molecular species of a given ganglioside are suggested to have distinct biological properties and regulate specific and distinct biological events. Elucidation of the function of each molecular species is important and will provide new insights into ganglioside biology. Gangliosides are also suggested to be involved in skeletal muscle differentiation; however, the differential roles of ganglioside molecular species remain unclear. Here we describe striking changes in quantity and quality of gangliosides (particularly GM3) during differentiation of mouse C2C12 myoblast cells and key roles played by distinct GM3 molecular species at each step of the process.
巻・号 292(17)
ページ 7040-7051
公開日 2017-4-28
DOI 10.1074/jbc.M116.771253
PII S0021-9258(20)42893-5
PMID 28275055
PMC PMC5409471
MeSH Animals Cell Differentiation* Cell Proliferation Ceramides / chemistry Chromatography, High Pressure Liquid Chromatography, Thin Layer G(M3) Ganglioside / chemistry* Glycosphingolipids / chemistry Lipids / chemistry Mass Spectrometry Mice Myoblasts / cytology* Myoblasts / metabolism N-Acetylneuraminic Acid / chemistry Signal Transduction
IF 4.238
引用数 7
リソース情報
ヒト・動物細胞 C2C12(RCB0987)