RRC ID |
33251
|
著者 |
Sasanami T, Izumi S, Sakurai N, Hirata T, Mizushima S, Matsuzaki M, Hiyama G, Yorinaga E, Yoshimura T, Ukena K, Tsutsui K.
|
タイトル |
A unique mechanism of successful fertilization in a domestic bird.
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ジャーナル |
Sci Rep
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Abstract |
Fertilization is an indispensable step for formation of a zygote in sexual reproduction, leading to species survival. When mating occurs, sperm is transported to the female reproductive tracts via the seminal plasma (SP). SP is derived from male accessory sex glands and it plays pivotal roles for fertilization in animals. However, molecular mechanisms of SP or a fluid derived from male accessory sex glands for successful fertilization remain unclear. Here, we report that in male quail the cloacal gland (CG) produces prostaglandin F2α (PGF2α) that contributes to successful fertilization. PGF2α, as well as the secretion of CG (CGS), induced vaginal contractions and caused the opening of the entrance of the sperm storage tubules, the structures responsible for the long-term sperm storage and fertilization. The removal of CGS from the male before mating reduced the fertility, but the supplementation of CGS or PGF2α rescued the subfertility. We further showed that male CG contains glucose that is utilized as energy source for the intrinsic sperm mobility after transportation to female vagina. This mechanism, in concert with the excitatory effects of PGF2α enables successful fertilization in the domestic bird.
|
巻・号 |
5
|
ページ |
7700
|
公開日 |
2015-1-9
|
DOI |
10.1038/srep07700
|
PII |
srep07700
|
PMID |
25572424
|
PMC |
PMC4287725
|
MeSH |
Animals
Animals, Domestic
Chromatography, High Pressure Liquid
Cloaca / metabolism
Dinoprost / analysis
Dinoprost / pharmacology
Female
Fertilization*
Male
Quail
Sperm Motility / physiology
Spermatozoa / physiology
Vagina / drug effects
Vagina / physiology
|
IF |
3.998
|
引用数 |
12
|
WOS 分野
|
REPRODUCTIVE BIOLOGY
|
リソース情報 |
ニワトリ・ウズラ |
|