RRC ID 33251
著者 Sasanami T, Izumi S, Sakurai N, Hirata T, Mizushima S, Matsuzaki M, Hiyama G, Yorinaga E, Yoshimura T, Ukena K, Tsutsui K.
タイトル A unique mechanism of successful fertilization in a domestic bird.
ジャーナル Sci Rep
Abstract Fertilization is an indispensable step for formation of a zygote in sexual reproduction, leading to species survival. When mating occurs, sperm is transported to the female reproductive tracts via the seminal plasma (SP). SP is derived from male accessory sex glands and it plays pivotal roles for fertilization in animals. However, molecular mechanisms of SP or a fluid derived from male accessory sex glands for successful fertilization remain unclear. Here, we report that in male quail the cloacal gland (CG) produces prostaglandin F2α (PGF2α) that contributes to successful fertilization. PGF2α, as well as the secretion of CG (CGS), induced vaginal contractions and caused the opening of the entrance of the sperm storage tubules, the structures responsible for the long-term sperm storage and fertilization. The removal of CGS from the male before mating reduced the fertility, but the supplementation of CGS or PGF2α rescued the subfertility. We further showed that male CG contains glucose that is utilized as energy source for the intrinsic sperm mobility after transportation to female vagina. This mechanism, in concert with the excitatory effects of PGF2α enables successful fertilization in the domestic bird.
巻・号 5
ページ 7700
公開日 2015-1-9
DOI 10.1038/srep07700
PII srep07700
PMID 25572424
PMC PMC4287725
MeSH Animals Animals, Domestic Chromatography, High Pressure Liquid Cloaca / metabolism Dinoprost / analysis Dinoprost / pharmacology Female Fertilization* Male Quail Sperm Motility / physiology Spermatozoa / physiology Vagina / drug effects Vagina / physiology
IF 3.998
引用数 12
WOS 分野 REPRODUCTIVE BIOLOGY
リソース情報
ニワトリ・ウズラ