| RRC ID |
52673
|
| 著者 |
Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T.
|
| タイトル |
Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.
|
| ジャーナル |
Development
|
| Abstract |
The evolution of unique organ structures is associated with changes in conserved developmental programs. However, characterizing the functional conservation and variation of homologous transcription factors (TFs) that dictate species-specific cellular dynamics has remained elusive. Here, we dissect shared and divergent functions of Pax6 during amniote brain development. Comparative functional analyses revealed that the neurogenic function of Pax6 is highly conserved in the developing mouse and chick pallium, whereas stage-specific binary functions of Pax6 in neurogenesis are unique to mouse neuronal progenitors, consistent with Pax6-dependent temporal regulation of Notch signaling. Furthermore, we identified that Pax6-dependent enhancer activity of Dbx1 is extensively conserved between mammals and chick, although Dbx1 expression in the developing pallium is highly divergent in these species. Our results suggest that spatiotemporal changes in Pax6-dependent regulatory programs contributed to species-specific neurogenic patterns in mammalian and avian lineages, which underlie the morphological divergence of the amniote pallial architectures.
|
| 巻・号 |
145(8)
|
| 公開日 |
2018-4-16
|
| DOI |
10.1242/dev.159764
|
| PII |
145/8/dev159764
|
| PMID |
29661783
|
| PMC |
PMC5964652
|
| MeSH |
Animals
Animals, Genetically Modified
Avian Proteins / genetics
Avian Proteins / physiology*
Brain / embryology*
Brain / physiology*
Chick Embryo
Enhancer Elements, Genetic
Evolution, Molecular
Female
Gene Deletion
Gene Expression Regulation, Developmental
Homeodomain Proteins / genetics
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Knockout
Mice, Transgenic
Neurogenesis / genetics
Neurogenesis / physiology
PAX6 Transcription Factor / deficiency
PAX6 Transcription Factor / genetics
PAX6 Transcription Factor / physiology*
Pregnancy
Receptors, Notch / genetics
Receptors, Notch / physiology
Signal Transduction
Species Specificity
|
| IF |
5.611
|
| 引用数 |
6
|
| リソース情報 |
| ヒト・動物細胞 |
293T(RCB2202) |
