RRC ID 33715
著者 Lee YM, Sun YH.
タイトル Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.
ジャーナル PLoS Genet
Abstract The late onset of neurodegeneration in humans indicates that the survival and function of cells in the nervous system must be maintained throughout adulthood. In the optic lamina of the adult Drosophila, the photoreceptor axons are surrounded by multiple types of glia. We demonstrated that the adult photoreceptors actively contribute to glia maintenance in their target field within the optic lamina. This effect is dependent on the epidermal growth factor receptor (EGFR) ligands produced by the R1-6 photoreceptors and transported to the optic lamina to act on EGFR in the lamina glia. EGFR signaling is necessary and sufficient to act in a cell-autonomous manner in the lamina glia. Our results suggest that EGFR signaling is required for the trafficking of the autophagosome/endosome to the lysosome. The loss of EGFR signaling results in cell degeneration most likely because of the accumulation of autophagosomes. Our findings provide in vivo evidence for the role of adult neurons in the maintenance of glia and a novel role for EGFR signaling in the autophagic flux.
巻・号 11(4)
ページ e1005187
公開日 2015-4-1
DOI 10.1371/journal.pgen.1005187
PII PGENETICS-D-14-02732
PMID 25909451
PMC PMC4409299
MeSH Animals Axons / metabolism Cell Differentiation / genetics* Drosophila / growth & development Drosophila / metabolism ErbB Receptors / genetics* Humans Neuroglia / metabolism* Neurons / metabolism Photoreceptor Cells, Invertebrate / metabolism Retina / metabolism* Retina / pathology Signal Transduction Spinal Cord Dorsal Horn / growth & development Spinal Cord Dorsal Horn / metabolism
IF 5.175
引用数 3
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ 3093R-4 12230R-1